消炎痛对雄性大鼠血浆中促黄体生成素和睾酮水平的影响。

Effect of indomethacin on blood plasma levels of LH and testosterone in male rats.

作者信息

Saksena S K, Lau I F, Bartke A, Chang M C

出版信息

J Reprod Fertil. 1975 Feb;42(2):311-7. doi: 10.1530/jrf.0.0420311.

DOI:10.1530/jrf.0.0420311

Abstract

Treatment of adult male rats with indomethacin, an inhibitor of prostaglandin (PG) synthesis, caused a significant decrease in LH and testosterone levels in the blood plasma and in the weight of the seminal vesicles, but the weight of the testes and ventral prostate, the levels of FSH in the plasma and fertility were not affected. The concentration of PGF in the blood plasma of the treated animals was reduced, even though measurable amounts of PGs were present in every group. The results of this study, together with the known effects of PG administration on LH release, suggest that the reduction of plasma LH levels in rats injected with indomethacin was due to decreased PG synthesis. It appears that PGs are normally involved in the regulation of LH release.

摘要

用消炎痛（一种前列腺素（PG）合成抑制剂）处理成年雄性大鼠，导致血浆中促黄体生成素（LH）和睾酮水平以及精囊重量显著降低，但睾丸和腹侧前列腺的重量、血浆中促卵泡生成素（FSH）水平和生育能力未受影响。尽管每组中都存在可测量量的PG，但处理动物的血浆中PGF浓度降低。本研究结果，连同已知的PG给药对LH释放的影响，表明注射消炎痛的大鼠血浆LH水平降低是由于PG合成减少所致。看来PG通常参与LH释放的调节。