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钾通道家族概述。

An overview of the potassium channel family.

作者信息

Miller C

机构信息

HHMI and Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA.

出版信息

Genome Biol. 2000;1(4):REVIEWS0004. doi: 10.1186/gb-2000-1-4-reviews0004. Epub 2000 Oct 13.

DOI:10.1186/gb-2000-1-4-reviews0004
PMID:11178249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC138870/
Abstract

Potassium channels, tetrameric integral membrane proteins that form aqueous pores through which K+ can flow, are found in virtually all organisms; the genomes of humans, Drosophila, and Caenorhabditis elegans contain 30-100 K+ channel genes each. The structure of a bacterial K+ channel, sequence comparisons with other channels and electrophysiological measurements have enabled conclusions about the mechanism of gating and ion flow to be drawn for many other channels.

摘要

钾通道是一种四聚体整合膜蛋白，可形成允许K+通过的水性孔道，几乎存在于所有生物体中；人类、果蝇和秀丽隐杆线虫的基因组中各自含有30 - 100个钾通道基因。细菌钾通道的结构、与其他通道的序列比较以及电生理测量，使得人们能够得出许多其他通道的门控机制和离子流动机制的结论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eec6/138870/3cb5b922300b/gb-2000-1-4-reviews0004-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eec6/138870/ee493585c47f/gb-2000-1-4-reviews0004-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eec6/138870/b1c09971b5ec/gb-2000-1-4-reviews0004-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eec6/138870/cf88e47d1f3b/gb-2000-1-4-reviews0004-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eec6/138870/3cb5b922300b/gb-2000-1-4-reviews0004-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eec6/138870/ee493585c47f/gb-2000-1-4-reviews0004-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eec6/138870/b1c09971b5ec/gb-2000-1-4-reviews0004-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eec6/138870/cf88e47d1f3b/gb-2000-1-4-reviews0004-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eec6/138870/3cb5b922300b/gb-2000-1-4-reviews0004-4.jpg

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Biochemistry. 2000 Aug 29;39(34):10347-52. doi: 10.1021/bi001292j.
2
Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels.电压依赖性钾离子通道胞质β亚基-T1组装体的结构
Science. 2000 Jul 7;289(5476):123-7. doi: 10.1126/science.289.5476.123.
3
Ion channels and synaptic organization: analysis of the Drosophila genome.离子通道与突触组织：果蝇基因组分析
人为极低频和无线通信电磁场对生物与健康影响的综合机制。
Front Public Health. 2025 Jun 4;13:1585441. doi: 10.3389/fpubh.2025.1585441. eCollection 2025.
4
Functional Characterization of Ion Channels in Planar Lipid Bilayers.平面脂质双分子层中离子通道的功能特性
Methods Mol Biol. 2025;2908:141-161. doi: 10.1007/978-1-0716-4434-8_10.
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The First K-Channel Blocker Described from Venom: The Purification, Molecular Cloning, and Functional Characterization of α-KTx4.9 (Tf5).首个从毒液中发现的钾离子通道阻滞剂：α-KTx4.9（Tf5）的纯化、分子克隆及功能特性研究
Toxins (Basel). 2025 Feb 18;17(2):96. doi: 10.3390/toxins17020096.
6
The novel quinoline derivative SKA-346 as a K3.1 channel selective activator.新型喹啉衍生物SKA-346作为K3.1通道选择性激活剂。
RSC Adv. 2024 Dec 4;14(52):38364-38377. doi: 10.1039/d4ra07330d. eCollection 2024 Dec 3.
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Sci Rep. 2024 Dec 3;14(1):30053. doi: 10.1038/s41598-024-77883-9.
8
Mathematical models of C-type and N-type inactivating heteromeric voltage gated potassium channels.C型和N型失活异源电压门控钾通道的数学模型。
Front Cell Neurosci. 2024 Oct 8;18:1418125. doi: 10.3389/fncel.2024.1418125. eCollection 2024.
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4
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