Bock C H, Cunningham J M, McDonnell S K, Schaid D J, Peterson B J, Pavlic R J, Schroeder J J, Klein J, French A J, Marks A, Thibodeau S N, Lange E M, Cooney K A
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Am J Hum Genet. 2001 Mar;68(3):795-801. doi: 10.1086/318797. Epub 2001 Feb 6.
A recent study of hereditary prostate cancer has provided evidence for a prostate cancer-susceptibility locus, HPC20, which maps to 20q13. To assess further the potential contribution of this locus to prostate cancer susceptibility, we studied 172 unrelated families affected by prostate cancer, using 17 polymorphic markers across a 98.5-cM segment of chromosome 20 that contains the candidate region. Parametric analysis, allowing for heterogeneity, resulted in an overall HLOD score of 0.09 (P=.39) at D20S171, under the assumption of linkage in 6% of families. Mode-of-inheritance-free analysis of the entire data set resulted in a maximal Zlr score of 0.76 (LOD 0.13; P=.22) at the same location. The strongest evidence for linkage was seen in the subset of 16 black families (LOD 0.86; Zlr=1.99; P=.023) between markers D20S893 and D20S120, near the putative location of HPC20. Although some positive results were observed, our linkage study does not provide statistically significant support for the existence of a prostate cancer-susceptibility locus HPC20 at 20q13.
最近一项关于遗传性前列腺癌的研究为一个前列腺癌易感基因座HPC20提供了证据，该基因座定位于20q13。为了进一步评估该基因座对前列腺癌易感性的潜在贡献，我们研究了172个患前列腺癌的无血缘关系家庭，使用了位于20号染色体上包含候选区域的98.5厘摩区段内的17个多态性标记。在6%的家庭存在连锁的假设下，考虑到基因座异质性的参数分析在D20S171处得出的总体HLOD分数为0.09（P = 0.39）。对整个数据集进行的无遗传模式分析在同一位置得出的最大Zlr分数为0.76（LOD 0.13；P = 0.22）。在16个黑人家庭的子集中，在靠近HPC20假定位置的标记D20S893和D20S120之间观察到了最强的连锁证据（LOD 0.86；Zlr = 1.99；P = 0.023）。尽管观察到了一些阳性结果，但我们的连锁研究并未为20q13处存在前列腺癌易感基因座HPC20提供统计学上的显著支持。
