Morshead C M, van der Kooy D
Department of Surgery, Division of Anatomy, University of Toronto, 1 Kings's College CircleMedical Science Building, Toronto, ON M5S 1A8, Canada.
Curr Opin Neurobiol. 2001 Feb;11(1):59-65. doi: 10.1016/s0959-4388(00)00174-4.
The existence of neural stem cells in the adult brain was essentially denied until the last decade. Within the past ten years, considerable progress has been made in examining the fundamental properties of neural stem cells. Most recently there has been much interest in the identification and precise location of the adult neural stem cells in vivo. Studies examining the localization of neural stem cells are controversial and suggest two distinct locations within the adult brain: the ependymal layer lining the ventricles, and the subependymal layer immediately adjacent to the ependyma.
直到过去十年，成体脑中神经干细胞的存在基本上都被否定。在过去十年里，在研究神经干细胞的基本特性方面取得了相当大的进展。最近，人们对成体神经干细胞在体内的鉴定和精确定位产生了浓厚兴趣。研究神经干细胞定位的研究存在争议，并表明在成体脑中存在两个不同的位置：脑室衬里的室管膜层，以及紧邻室管膜的室管膜下层。
