Arsenijevic Yvan
Department of Ophthalmology, Jules Gonin Eye Hospital, Lusanne University Medical School, Switzerland.
Mol Neurobiol. 2003 Feb;27(1):73-98. doi: 10.1385/MN:27:1:73.
Recent data show that the final events of mammalian brain organogenesis may depend in part on the direct control of neural stem cell (NSC) proliferation and survival. Environmental and intrinsic factors play a role throughout development and during adulthood to regulate NSC proliferation. The NSCs acquire new competences throughout development, including adulthood, and this change in competence is region-specific. The factors controlling NSC survival, undifferentiated state, proliferation, and cell-cycle number are beginning to be identified, but the links between them remain unclear. However, current knowledge should help to formulate an understanding of how a stem cell can generate a new stem cell.
近期数据表明，哺乳动物脑器官发生的最终事件可能部分取决于神经干细胞（NSC）增殖和存活的直接调控。环境和内在因素在整个发育过程及成年期都发挥作用，以调节NSC增殖。NSC在整个发育过程（包括成年期）中获得新的能力，且这种能力的变化具有区域特异性。控制NSC存活、未分化状态、增殖及细胞周期数量的因素已开始被确定，但它们之间的联系仍不明确。然而，目前的知识应有助于形成对干细胞如何产生新干细胞的理解。
