Le Goff L, Beljanski M
C R Seances Acad Sci D. 1979 Jan 8;288(1):147-50.
RNA-fragments U2 obtained by mild degradation with RNase U2 of ribosomal RNA containing A and G nucleotides in excess are capable of exhibiting either a stimulatory effect on the induction of Crown-gall tumors or an inhibitory action on their subsequent development. These different effects are dependent on the moment at which RNA-fragments were introduced into wounded Pea seedlings infected by Agrobacterium tumefaciens B6. The results obtained in vitro and in vivo suggest that an interaction between auxin and RNA-fragments U2 may take place, either increasing the tumor induction or inhibiting the proliferation of tumourous cells.
通过用核糖核酸酶U2对含有过量A和G核苷酸的核糖体RNA进行温和降解而获得的RNA片段U2,能够对冠瘿瘤的诱导表现出刺激作用,或者对其后续发展产生抑制作用。这些不同的效应取决于将RNA片段引入被根癌土壤杆菌B6感染的受伤豌豆幼苗的时刻。体外和体内获得的结果表明,生长素与RNA片段U2之间可能发生相互作用,要么增加肿瘤诱导,要么抑制肿瘤细胞的增殖。