Hayashi A, Kobayashi A, Takahashi R, Suzuki F, Nakagawa T, Kimotro K
Department of Nutrition, Tokyo Kasei University, Japan.
J Nutr Sci Vitaminol (Tokyo). 2000 Aug;46(4):165-70. doi: 10.3177/jnsv.46.165.
The effect of a voluntary running exercise on blood pressure and renin-angiotensin system (RAS) was studied in male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). SHR and WKY were assigned to either voluntary running exercise or sedentary control groups at 5 wk of age. The systolic blood pressure in the exercised group for both strains of rats was significantly lower than in the sedentary control group. The plasma renin activity (PRA) and plasma renin concentration (PRC) were significantly lower in voluntary running exercised SHR than in sedentary SHR, whereas the same exercise did not result in a lower PRA and PRC in WKY. These results suggested that the blood pressure lowering effect of voluntary running exercise is related to the suppression of RAS in SHR.
在雄性自发性高血压大鼠（SHR）和正常血压的Wistar-Kyoto大鼠（WKY）中研究了自愿跑步运动对血压和肾素-血管紧张素系统（RAS）的影响。SHR和WKY在5周龄时被分为自愿跑步运动组或久坐对照组。两种品系大鼠的运动组收缩压均显著低于久坐对照组。自愿跑步运动的SHR的血浆肾素活性（PRA）和血浆肾素浓度（PRC）显著低于久坐的SHR，而相同的运动并未使WKY的PRA和PRC降低。这些结果表明，自愿跑步运动的降压作用与SHR中RAS的抑制有关。
