Alexander G A, Chu K C, Ho R C
Office of Special Populations Research, National Cancer Institute, Bethesda, MD 20892-7161, USA.
Ann Epidemiol. 2000 Nov;10(8 Suppl):S61-67. doi: 10.1016/s1047-2797(00)00198-8.
The objectives of this study are to analyze the accrual of Asian Americans to National Cancer Institute (NCI)-supported prevention, screening/diagnosis, and treatment trials and to determine if there is proportional ethnic representation.
Data were obtained on all participants accrued to ongoing prevention and screening/ diagnosis trials and on all patients accrued to treatment trials from 1994 to mid-1998. In the analysis, the percentage of Asian Americans to the total number of trial participants is calculated. For treatment trials, participants were stratified into five age groups: 0-20 years, 21-44 years, 45-54 years, 55-64 years, and 65 or more years.
Asian Americans represented 4.8% of subjects accrued in screening/diagnosis trials, 1.8 to 2.2% of subjects in treatment trials, and 0.9% of subjects in prevention trials. Comparison of treatment trial age groups revealed that younger Asian Americans participate significantly more in treatment trials than older Asian Americans.
Asian American accrual in NCI-supported trials is representative of the cancer burden of Asian Americans in the United States. However, Asian Americans 65+ years are underrepresented. Their full participation in cancer trials is justified.
本研究的目的是分析亚裔美国人参与美国国立癌症研究所（NCI）资助的预防、筛查/诊断及治疗试验的情况，并确定是否存在按比例的种族代表性。
获取了1994年至1998年年中所有参与正在进行的预防和筛查/诊断试验的参与者以及所有参与治疗试验的患者的数据。在分析中，计算了亚裔美国人在试验参与者总数中的百分比。对于治疗试验，参与者被分为五个年龄组：0至20岁、21至44岁、45至54岁、55至64岁以及65岁及以上。
亚裔美国人在筛查/诊断试验的受试者中占4.8%，在治疗试验的受试者中占1.8%至2.2%，在预防试验的受试者中占0.9%。治疗试验年龄组的比较显示，较年轻的亚裔美国人比年长的亚裔美国人更多地参与治疗试验。
亚裔美国人参与NCI资助试验的情况代表了美国亚裔美国人的癌症负担。然而，65岁及以上的亚裔美国人代表性不足。他们充分参与癌症试验是合理的。
