Yen Glorian P, Davey Adam, Ma Grace X
1 Department of Public Health, Temple University , Philadelphia, Pennsylvania.
Biopreserv Biobank. 2015 Apr;13(2):107-13. doi: 10.1089/bio.2014.0028. Epub 2015 Apr 8.
Biorepositories have been key resources in examining genetically-linked diseases, particularly cancer. Asian Americans contribute to biorepositories at lower rates than other racial groups, but the reasons for this are unclear. We hypothesized that attitudes toward biospecimen research mediate the relationship between demographic and healthcare access factors, and willingness to donate blood for research purposes among individuals of Korean heritage.
Descriptive statistics and bivariate analyses were utilized to characterize the sample with respect to demographic, psychosocial, and behavioral variables. Structural equation modeling with 5000 re-sample bootstrapping was used to assess each component of the proposed simple mediation models.
Attitudes towards biospecimen research fully mediate associations between age, income, number of years lived in the United States, and having a regular physician and willingness to donate blood for the purpose of research.
Participants were willing to donate blood for the purpose of research despite having neutral feelings towards biospecimen research as a whole. Participants reported higher willingness to donate blood for research purposes when they were older, had lived in the United States longer, had higher income, and had a regular doctor that they visited. Many of the significant relationships between demographic and health care access factors, attitudes towards biospecimen research, and willingness to donate blood for the purpose of research may be explained by the extent of acculturation of the participants in the United States.
生物样本库一直是研究基因相关疾病(尤其是癌症)的关键资源。亚裔美国人向生物样本库的贡献率低于其他种族群体,但其原因尚不清楚。我们假设,对于韩裔个体而言,对生物样本研究的态度在人口统计学因素、医疗保健获取因素与为研究目的献血意愿之间的关系中起中介作用。
运用描述性统计和双变量分析来描述样本在人口统计学、心理社会和行为变量方面的特征。采用具有5000次重新抽样自举法的结构方程模型来评估所提出的简单中介模型的每个组成部分。
对生物样本研究的态度完全中介了年龄、收入、在美国居住的年数、是否有固定医生与为研究目的献血意愿之间的关联。
尽管参与者对生物样本研究总体持中立态度,但他们愿意为研究目的献血。当参与者年龄较大、在美国居住时间较长、收入较高且有定期就诊的医生时,他们报告出更高的为研究目的献血意愿。人口统计学因素与医疗保健获取因素、对生物样本研究的态度以及为研究目的献血意愿之间的许多显著关系,可能可以通过参与者在美国的文化适应程度来解释。