Rodríguez de Fonseca F, Roberts A J, Bilbao A, Koob G F, Navarro M
Instituto Complutense de Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid, 28223-Madrid, Spain.
Zhongguo Yao Li Xue Bao. 1999 Dec;20(12):1109-14.
To study the potential role of dependence status on CB1-mediated blockade of ethanol self-administration.
We examined the effects of the cannabinoid antagonist SR141716A (0, 0.03, 0.3, and 3 mg/kg) on operant ethanol (10% v/v) self-administration in male Wistar rats that were made ethanol-dependent by chronic (14 d) exposure to ethanol vapor-chambers or exposed to air in identical vapor chambers.
Dependent animals responded more for ethanol than did air control nondependent rats. The acute administration of a 3 mg/kg dose of SR141716A almost suppressed ethanol self-administration only in ethanol dependent animals. However, operant responses for food were not affected by the administration of SR141716A.
These results further support that cannabinoid CB1 receptor blockade may have a potential utility for the treatment of alcoholism.
研究依赖状态对CB1介导的乙醇自我给药阻断作用的潜在影响。
我们检测了大麻素拮抗剂SR141716A（0、0.03、0.3和3mg/kg）对雄性Wistar大鼠操作性乙醇（10%体积/体积）自我给药的影响，这些大鼠通过慢性（14天）暴露于乙醇蒸汽室或在相同蒸汽室中暴露于空气中而产生乙醇依赖。
与空气对照的非依赖大鼠相比，依赖动物对乙醇的反应更多。急性给予3mg/kg剂量的SR141716A仅在乙醇依赖动物中几乎抑制了乙醇自我给药。然而，SR141716A的给药对食物的操作性反应没有影响。
这些结果进一步支持大麻素CB1受体阻断可能对治疗酒精中毒具有潜在作用。
