Vinklerová Jana, Nováková Jana, Sulcová Alexandra
Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
J Psychopharmacol. 2002 Jun;16(2):139-43. doi: 10.1177/026988110201600204.
Cannabinoids are drugs that are frequently abused not only alone, but also in combination with other drugs. The present study investigated possible functional interactions between the psychostimulant methamphetamine and the cannabinoid receptor agonists anandamide, or R-(+)-methanandamide and cannabinoid antagonist AM 251 in the rat model of i.v. drug self-administration. In rats trained to self-administer methamphetamine, the intake was significantly decreased by the cannabinoid antagonist and tended to be dose-dependently increased by pre-treatment with cannabinoid receptor agonists. Possible mechanisms for these drug interactions are discussed and the use of the cannabinoid antagonist for the treatment of drug abuse is considered.
大麻素类药物不仅经常被单独滥用，还会与其他药物混合使用。本研究在静脉注射药物自我给药的大鼠模型中，研究了精神兴奋剂甲基苯丙胺与大麻素受体激动剂花生四烯乙醇胺或R-(+)-甲基花生四烯酸乙醇胺以及大麻素拮抗剂AM 251之间可能存在的功能相互作用。在经过训练可自我给药甲基苯丙胺的大鼠中，大麻素拮抗剂显著降低了药物摄入量，而大麻素受体激动剂预处理则呈现出剂量依赖性增加的趋势。本文讨论了这些药物相互作用的可能机制，并考虑了使用大麻素拮抗剂治疗药物滥用的情况。
