Kadanka Z, Bednarík J, Vohánka S, Vlach O, Stejskal L, Chaloupka R, Filipovicová D, Surelová D, Adamová B, Novotný O, Nemec M, Smrcka V, Urbánek I
Department of Neurology, Faculty Hospital Brno, Czech Republic.
Eur Spine J. 2000 Dec;9(6):538-44. doi: 10.1007/s005860000132.
A prospective randomised 2-year study was performed to compare the conservative and operative treatment of mild and moderate forms of spondylotic cervical myelopathy (SCM). Forty-eight patients presenting with the clinical syndrome of SCM, with a modified Japanese Orthopaedic Association (mJOA) score of 12 points or more, were randomised into two groups. Group A, treated conservatively, consisted of 27 patients, mean age 55.6 +/- 8.6 years, while group B was treated surgically (21 patients, mean age 52.7 +/- 8.1 years). The clinical outcome was measured by the mJOA score, recovery rate (RR), timed 10 m walk, score of daily activities (recorded by video and evaluated by two observers blinded to the therapy), and by the subjective assessment of the patients at 6, 12, and 24 months of the follow-up. There was, on average, no significant deterioration in mJOA score, recovery ratio, or timed 10 m walk within either group during the 2 years of follow-up. In the surgery group there was a slight decline in the scores for daily activities and subjective evaluation. A comparison of the two groups showed no significant differences in changes over time in mJOA score or quantified gait, but there were significant differences in the score of daily activities recorded by video at 24 months, which was a little lower in the surgical group, and also in RR and subjective evaluation, which were both worse in the surgical group at months 12 and 24. However, at month 6, this last parameter was significantly better in the surgical than in conservative group. Surgical treatment of mild and moderate forms of SCM in the present study design, comprising the patients with no or very slow, insidious progression and a relatively long duration of symptoms, did not show better results than conservative treatment over the 2-year follow-up.
进行了一项为期2年的前瞻性随机研究,以比较轻度和中度脊髓型颈椎病(SCM)的保守治疗和手术治疗。48例表现出SCM临床综合征、改良日本骨科协会(mJOA)评分在12分及以上的患者被随机分为两组。A组采用保守治疗,共27例患者,平均年龄55.6±8.6岁;B组采用手术治疗(21例患者,平均年龄52.7±8.1岁)。通过mJOA评分、恢复率(RR)、10米定时步行、日常活动评分(通过视频记录并由两名对治疗不知情的观察者评估)以及在随访6、12和24个月时患者的主观评估来衡量临床结果。在2年的随访期间,两组内mJOA评分、恢复率或10米定时步行平均均无显著恶化。手术组的日常活动评分和主观评估略有下降。两组比较显示,mJOA评分或定量步态随时间的变化无显著差异,但在24个月时通过视频记录的日常活动评分存在显著差异,手术组略低,RR和主观评估在12个月和24个月时手术组也较差。然而,在6个月时,手术组的这最后一项参数明显优于保守组。在本研究设计中,对轻度和中度SCM患者(包括无进展或进展非常缓慢、隐匿且症状持续时间相对较长的患者)进行手术治疗,在2年的随访中并未显示出比保守治疗更好的效果。