Hlastala S A, Frank E, Kowalski J, Sherrill J T, Tu X M, Anderson B, Kupfer D J
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, Pennsylvania 15213, USA.
J Abnorm Psychol. 2000 Nov;109(4):777-86. doi: 10.1037//0021-843x.109.4.777.
A common misconception is that bipolar disorder is an endogenous process. However, previous research suggests a role for life events in the onset of and recovery from bipolar episodes. Yet, there remains some question as to whether the relationship between life events and onset changes over the course of the disorder as a result of the number of episodes an individual has experienced. Using a rigorous interview measure of stressful life events, the current study tested the kindling model (R. M. Post, 1992), which theorizes that major life events play a diminishing role over the course of illness in bipolar patients. Analyses revealed that the number of episodes experienced does not appear to have a significant effect on bipolar 1 patients' reactivity to external stressors. In addition, the results suggest that a more complex relationship exists among age, stress, and onset of new episodes than can be adequately explained by the kindling model.
一个常见的误解是双相情感障碍是一个内生过程。然而，先前的研究表明生活事件在双相情感发作的起始及恢复过程中起作用。然而，对于生活事件与发作之间的关系是否会因个体经历的发作次数而在疾病过程中发生变化，仍存在一些疑问。本研究使用一种严格的应激性生活事件访谈测量方法，检验了点燃模型（R.M.波斯特，1992年），该模型认为重大生活事件在双相情感障碍患者的病程中作用逐渐减弱。分析表明，经历的发作次数似乎对双相I型障碍患者对外界应激源的反应性没有显著影响。此外，结果表明年龄、应激与新发作的起始之间存在比点燃模型所能充分解释的更为复杂的关系。
