Schmid A, Dordick J S, Hauer B, Kiener A, Wubbolts M, Witholt B
Institute of Biotechnology, ETH-Hönggerberg, Zürich, Switzerland.
Nature. 2001 Jan 11;409(6817):258-68. doi: 10.1038/35051736.
The use of biocatalysis for industrial synthetic chemistry is on the verge of significant growth. Biocatalytic processes can now be carried out in organic solvents as well as aqueous environments, so that apolar organic compounds as well as water-soluble compounds can be modified selectively and efficiently with enzymes and biocatalytically active cells. As the use of biocatalysis for industrial chemical synthesis becomes easier, several chemical companies have begun to increase significantly the number and sophistication of the biocatalytic processes used in their synthesis operations.
生物催化在工业合成化学中的应用正处于显著增长的边缘。生物催化过程现在既可以在有机溶剂中进行,也可以在水性环境中进行,这样非极性有机化合物以及水溶性化合物都可以通过酶和具有生物催化活性的细胞进行选择性和高效的修饰。随着生物催化在工业化学合成中的应用变得更加容易,几家化学公司已经开始大幅增加其合成操作中使用的生物催化过程的数量和复杂性。