Bonciolini Stefano, Pulcinella Antonio, Noël Timothy
Flow Chemistry Group, Van 't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands.
J Am Chem Soc. 2025 Aug 13;147(32):28523-28545. doi: 10.1021/jacs.5c10303. Epub 2025 Aug 5.
Recent years have witnessed growing interest in integrating enabling technologies into synthetic organic chemistry to address long-standing challenges in reproducibility, sustainability, and scalability. This perspective showcases how modern tools, ranging from continuous-flow reactors and electrochemical cells to photochemical technologies, biocatalysis, mechanochemistry, and self-driving laboratories, are reshaping the way chemists design, perform, and optimize reactions. Through selected case studies, we highlight how these technologies not only solve specific reactivity and process issues but also open new avenues for reactivity discovery and chemical innovation. Rather than viewing technology as a complication, we advocate for its adoption as a natural extension of synthetic creativity, capable of enhancing safety, reducing waste, and expanding accessible chemical space. Our aim is to inspire broader implementation and interdisciplinary training to equip the next generation of chemists with the tools to rethink how synthesis is performed in the 21st century.
近年来，人们越来越关注将使能技术整合到合成有机化学中，以应对在可重复性、可持续性和可扩展性方面长期存在的挑战。本文展示了从连续流反应器、电化学电池到光化学技术、生物催化、机械化学和自动驾驶实验室等现代工具如何重塑化学家设计、进行和优化反应的方式。通过选定的案例研究，我们强调这些技术不仅解决了特定的反应性和工艺问题，还为反应性发现和化学创新开辟了新途径。我们主张将技术视为合成创造力的自然延伸，而不是将其视为一种复杂性，它能够提高安全性、减少浪费并扩大可及的化学空间。我们的目标是激发更广泛的应用和跨学科培训，为下一代化学家配备工具，以重新思考21世纪合成是如何进行的。
