Ozawa S, Sawada J
Division of Pharmacology, Biological Safety Research Center, National Institute of Health Sciences.
Nihon Rinsho. 2001 Jan;59(1):195-201.
Progress in the field of pharmacogenetics has revealed that the phenotypically different responses of patients to drugs are genetically determined by the polymorphisms in the genes involved in their pharmacokinetics and pharmacodynamics. Information on genetic polymorphisms, including single nucleotide polymorphisms, found in the genes encoding drug-metabolizing enzymes, drug transporters, drug receptors, and so on, are now applicable to tailor-made(individualized) drug therapy. This report presents the current status of pharmacogenetic approaches to the individualized therapy.
药物遗传学领域的进展表明，患者对药物在表型上的不同反应是由其药物代谢动力学和药效学相关基因中的多态性所决定的。在编码药物代谢酶、药物转运体、药物受体等基因中发现的包括单核苷酸多态性在内的基因多态性信息，目前已适用于定制（个体化）药物治疗。本报告介绍了个体化治疗的药物遗传学方法的现状。
