Meyer J H, Ichise M
PET Imaging Centre, 11th floor, Clarke Division, CAMH, 250 College St., Department of Psychiatry, University of Toronto, Ontario, Canada M5T 1R8.
J Neuroimaging. 2001 Jan;11(1):30-9. doi: 10.1111/j.1552-6569.2001.tb00006.x.
Over the past decade, a number of new kinetic modeling techniques have been developed for PET and SPECT ligands. This article will review commonly used modeling solutions for reversible positron-emission tomography (PET) and single photon emission computed tomography (SPECT) radioligands, with an emphasis on noninvasive methods. All of the modeling approaches in PET and SPECT assume a compartmental system and derive parameters that describe the compartmental system. These parameters will be defined, and their relationship to analogous parameters in pharmacology will be discussed. Then the major approaches are presented under the categories of graphical or mathematical as well as invasive or noninvasive.
在过去十年中，已经为正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）配体开发了许多新的动力学建模技术。本文将回顾用于可逆性正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）放射性配体的常用建模方法，重点是无创方法。PET和SPECT中的所有建模方法都假定为一个房室系统，并推导描述该房室系统的参数。将定义这些参数，并讨论它们与药理学中类似参数的关系。然后，将在图形或数学以及有创或无创的类别下介绍主要方法。
