Lammertsma A A
PET Centre, University Hospital, Vrije Universiteit, PO Box 7057, 1022 MB, Amsterdam, The Netherlands.
Vision Res. 2001;41(10-11):1277-81. doi: 10.1016/s0042-6989(00)00262-5.
In this review, first principles of positron emission tomography (PET) and single photon emission tomography (SPECT) are discussed together with the relative strengths and weaknesses of both techniques. With both modalities it is possible to image and, especially with PET, to measure regional tissue function, the particular function being interrogated depending on the actual tracer being used. In the second part, the use of PET for neuroactivation studies is presented, illustrated with some key examples from the literature using both perfusion and metabolism tracers. It is argued that the future of PET (and SPECT) neuroactivation studies lies in the use of ligands. Possible approaches for performing ligand activation studies are discussed.
在本综述中，正电子发射断层扫描（PET）和单光子发射断层扫描（SPECT）的基本原理与这两种技术各自的优缺点一同被讨论。使用这两种模式都能够进行成像，尤其是PET，还能够测量局部组织功能，具体所研究的功能取决于所使用的实际示踪剂。在第二部分中，介绍了PET在神经激活研究中的应用，并列举了文献中使用灌注和代谢示踪剂的一些关键实例加以说明。有人认为，PET（以及SPECT）神经激活研究的未来在于配体的使用。文中还讨论了进行配体激活研究的可能方法。
