Watabe Hiroshi, Ikoma Yoko, Kimura Yuichi, Naganawa Mika, Shidahara Miho
Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan.
Ann Nucl Med. 2006 Nov;20(9):583-8. doi: 10.1007/BF02984655.
PET enables not only visualization of the distribution of radiotracer, but also has ability to quantify several biomedical functions. Compartmental model is a basic idea to analyze dynamic PET data. This review describes the principle of the compartmental model and categorizes the techniques and approaches for the compartmental model according to various aspects: model design, experimental design, invasiveness, and mathematical solution. We also discussed advanced applications of the compartmental analysis with PET.
正电子发射断层扫描（PET）不仅能够可视化放射性示踪剂的分布，还具备量化多种生物医学功能的能力。房室模型是分析动态PET数据的基本理念。本综述阐述了房室模型的原理，并根据模型设计、实验设计、侵入性和数学求解等多个方面，对房室模型的技术和方法进行了分类。我们还讨论了PET房室分析的高级应用。
