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Ann Surg. 1975 Jan;181(1):81-4. doi: 10.1097/00000658-197501000-00017.
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[Carcinoembryonic antigen (CEA) in surgically treated cancer of the large intestine].[手术治疗的大肠癌中的癌胚抗原（CEA）]
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Klin Wochenschr. 1980 Feb 1;58(3):125-33. doi: 10.1007/BF01477269.
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Monoclonal antibody detection of a circulating tumor-associated antigen. II. A longitudinal evaluation of patients with colorectal cancer.循环肿瘤相关抗原的单克隆抗体检测。II. 结直肠癌患者的纵向评估。
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The prognostic significance of preoperative carcinoembryonic antigen levels in colorectal cancer. Results from NSABP (National Surgical Adjuvant Breast and Bowel Project) clinical trials.结直肠癌术前癌胚抗原水平的预后意义。来自NSABP（国家外科辅助乳腺和肠道项目）临床试验的结果。
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本文引用的文献

1
DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES.通过免疫耐受和吸收技术证明人类结肠癌中的肿瘤特异性抗原
J Exp Med. 1965 Mar 1;121(3):439-62. doi: 10.1084/jem.121.3.439.
2
The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system.人消化系统循环癌胚抗原的放射免疫测定
Proc Natl Acad Sci U S A. 1969 Sep;64(1):161-7. doi: 10.1073/pnas.64.1.161.
3
Response of lymphocytes from patients with gastrointestinal cancer to the carcinoembryonic antigen of the human digestive system.胃肠道癌患者淋巴细胞对人消化系统癌胚抗原的反应。
Cancer. 1971 Jul;28(1):115-20. doi: 10.1002/1097-0142(197107)28:1<115::aid-cncr2820280121>3.0.co;2-k.
4
Demonstration of an antigen common to several varieties of neoplasia.几种肿瘤共同抗原的证实。
N Engl J Med. 1971 Jul 15;285(3):138-41. doi: 10.1056/NEJM197107152850302.
5
Carcinoembryonic antigen (CEA) in patients with carcinoma of the digestive tract.消化道癌患者的癌胚抗原（CEA）
Ann Surg. 1972 Oct;176(4):559-64. doi: 10.1097/00000658-197217640-00015.
6
Role of plasma carcinoembryonic antigen in diagnosis of gastrointestinal, mammary, and bronchial carcinoma.血浆癌胚抗原在胃肠道、乳腺癌和支气管癌诊断中的作用。
Br Med J. 1972 Sep 9;3(5827):605-9. doi: 10.1136/bmj.3.5827.605.
7
Absence of circulating antibodies to carcinoembryonic antigen in patients with gastrointestinal malignancies.胃肠道恶性肿瘤患者体内缺乏癌胚抗原循环抗体。
Int J Cancer. 1972 Mar 15;9(2):344-8. doi: 10.1002/ijc.2910090212.
8
Tumor-associated (CEA-reacting) antigen in patients with inflammatory bowel disease.炎症性肠病患者的肿瘤相关（癌胚抗原反应性）抗原
N Engl J Med. 1972 Jul 6;287(1):24-6. doi: 10.1056/NEJM197207062870106.
9
Tumor-associated antigen in patients with carcinoma of the colon.结肠癌患者的肿瘤相关抗原。
Am J Surg. 1972 Feb;123(2):127-31. doi: 10.1016/0002-9610(72)90321-2.
10
Further investigations of circulating antibodies in colon cancer patients: on the autoantigenicity of the carcinoembryonic antigen.结肠癌患者循环抗体的进一步研究：关于癌胚抗原的自身抗原性
Int J Cancer. 1971 Sep 15;8(2):298-303. doi: 10.1002/ijc.2910080215.

癌胚抗原与结肠癌患者的预后

Carcinoembryonic antigen and prognosis in patients with colon cancer.

作者信息

Lo Gerfo P, Herter F P

出版信息

Ann Surg. 1975 Jan;181(1):81-4. doi: 10.1097/00000658-197501000-00017.

DOI:10.1097/00000658-197501000-00017
PMID:1119871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1343719/
Abstract

One-hundred and fifty patients with non-metastatic colo-rectal cancer were followed for a period of 24 to 36 months postoperatively. Preoperative CEA values have been shown to correlate with the extent of the disease and the patient's prognosis. The prognosis for recurrences is greater in patients with elevated pre-operative CEA values regardless of the stage of their disease. This tendency to have recurrences is 1.8 times higher in individuals with increased pre-operative CEA levels. This same relationship occurs to a greater or lesser extent at each stage of the disease.

摘要

150例非转移性结直肠癌患者在术后接受了24至36个月的随访。术前癌胚抗原（CEA）值已被证明与疾病程度和患者预后相关。无论疾病处于何阶段，术前CEA值升高的患者复发预后更差。术前CEA水平升高的个体复发倾向高1.8倍。在疾病的每个阶段或多或少都存在这种相同的关系。