Marsland A L, Cohen S, Rabin B S, Manuck S B
Behavioral Medicine Program, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213-2593, USA.
Health Psychol. 2001 Jan;20(1):4-11.
Eighty-four healthy graduate participants were administered the standard course of 3 hepatitis B vaccinations. Five months after the first dose (shortly after the second injection), each participant completed psychosocial measures, and a blood sample was drawn for determination of hepatitis B surface antibody titer. After completion of the vaccination series, participants performed an acute stress protocol, consisting of a 30-min adaptation period and a 5-min evaluative speech task. Blood was drawn at the end of the resting and task periods for assessment of cellular immune measures. Lower antibody response, as assessed after the second hepatitis B injection, was predicted independently by (a) high trait negative affect and (b) diminished T-cell proliferation in response to PHA. These data provide evidence that trait negative affect and the magnitude of stress-induced suppression of immune function may have clinical significance.
84名健康的研究生参与者接受了3次标准的乙肝疫苗接种。在第一剂疫苗接种后5个月（第二次注射后不久），每位参与者完成心理社会测量，并采集血样以测定乙肝表面抗体滴度。在完成疫苗接种系列后，参与者进行了一项急性应激试验，包括30分钟的适应期和5分钟的评估性演讲任务。在休息期和任务期结束时采集血液，以评估细胞免疫指标。在第二次乙肝注射后评估发现，较低的抗体反应分别由以下因素独立预测：(a) 高特质消极情绪；(b) 对PHA反应时T细胞增殖减少。这些数据表明，特质消极情绪和应激诱导的免疫功能抑制程度可能具有临床意义。
