Mayr B, Resch S, Hepperle S, Brem G, Reifinger M, Schaffner G
Institute for Animal Breeding and Genetics, Veterinary University Vienna, Austria.
J Vet Med A Physiol Pathol Clin Med. 2000 Dec;47(10):593-7. doi: 10.1046/j.1439-0442.2000.00322.x.
Tumour suppressor p53 is critical in a broad panel of tumour types in human, mouse and other mammals. Regions of the promoter and exon 1 play an important role in expression of p53. In the present study, the DNA sequences of promoter and exon 1 regions of four domestic animal species (dog, cat, horse and cattle) are determined and compared with experimental rodents (mouse, rat and hamster) and man. A broad panel of tumour types have been investigated for mutations in this regulatory area in 90 canine, 136 feline, 25 equine and 10 bovine patients. No mutation was detected in any of the tumours analysed.
肿瘤抑制因子p53在人类、小鼠和其他哺乳动物的多种肿瘤类型中至关重要。启动子区域和外显子1在p53的表达中发挥重要作用。在本研究中，测定了四种家畜（狗、猫、马和牛）启动子和外显子1区域的DNA序列，并与实验啮齿动物（小鼠、大鼠和仓鼠）及人类进行比较。对90例犬类、136例猫科、25例马科和10例牛科患者的多种肿瘤类型进行了该调控区域突变的研究。在所分析的任何肿瘤中均未检测到突变。
