Stabholz A, Shapira L, Mahler D, Gellman Y, Ramon T, Dolev E, Schwartz M, Berger L, Proskin H M, Finkelman R D, Flashner M, Kolatch B, Soskolne A
Department of Community Dentistry, Hebrew University, Hadassah Faculty of Dental Medicine, Jerusalem, Israel.
Compend Contin Educ Dent. 2000 Apr;21(4):325-8, 330, 332 passim; quiz 338.
Multicenter clinical trials have established that the adjunctive use of the subgingival controlled release of chlorhexidine, in the form of the PerioChip, significantly reduces pocket probing depth, improves probing attachment levels, and reduces bleeding on probing compared to scaling and root planing alone, for periods up to 9 months. The purpose of the present study was to report on the adjunctive use of the PerioChip for the long-term management of adult periodontitis for 2 years. A total of 836 patients with adult periodontitis from private dental offices were recruited into the trial. This interim report is on the first 72 patients to have completed the 2-year study. Treatments included initial definitive therapy followed by PerioChip placement in pocket sites with a pocket probing depth of > or = 5 mm after 1 month. Subsequently, the patients received routine periodontal maintenance therapy together with the placement of a PerioChip in pockets with pocket probing depths > or = 5 mm every 3 months. Results indicated that there was a continuous decrease in pocket probing depth over the 2 years (1.26 +/- 0.77 mm). This decrease in pocket probing depth was marked over the first 9 to 12 months, and then appeared to be less marked over the next 12 months. At 2 years, 60% of the patients had at least 2 pockets showing a reduction of 2 mm or more, and only 10% of the patients showed no change or increased pocket probing depth. The results indicate that adjunctive PerioChip use is a clinically effective treatment option for dental professionals and their patients for the long-term management of adult periodontitis.
多中心临床试验已证实，以PerioChip形式龈下控释洗必泰，与单纯龈上洁治和根面平整相比，在长达9个月的时间内，能显著降低牙周袋探诊深度，改善探诊附着水平，并减少探诊出血。本研究的目的是报告PerioChip辅助治疗成人牙周炎2年的长期效果。共有836名来自私人牙科诊所的成人牙周炎患者被纳入该试验。这份中期报告是关于首批72名完成2年研究的患者。治疗包括初始确定性治疗，1个月后在牙周袋探诊深度≥5mm的部位放置PerioChip。随后，患者接受常规牙周维护治疗，并每3个月在牙周袋探诊深度≥5mm的部位放置一次PerioChip。结果表明，在2年期间牙周袋探诊深度持续下降（1.26±0.77mm）。在最初的9至12个月，牙周袋探诊深度下降明显，而在接下来的12个月似乎下降不太明显。在2年时，60%的患者至少有2个牙周袋探诊深度减少2mm或更多，只有10%的患者牙周袋探诊深度无变化或增加。结果表明，对于牙科专业人员及其患者而言，辅助使用PerioChip是成人牙周炎长期管理的一种临床有效治疗选择。
