Carvalho Juliana, Novak M John, Mota Luis F
Department of Periodontics, School of Dentistry, Loma Linda University, Loma Linda, CA, USA.
J Periodontol. 2007 Jun;78(6):997-1001. doi: 10.1902/jop.2007.060122.
The purpose of this 9-month study was to compare the effect of scaling and root planing alone (control) to that of scaling and root planing plus application of chlorhexidine chips (test).
Twenty-six subjects having two non-adjacent sites in non-molar teeth with probing depth > or =5 mm and bleeding on probing participated in this split-mouth trial. At baseline, the patients received full-mouth scaling and root planing followed by placement of chlorhexidine chips secured by cyanoacrylate at test sites and placement of cyanoacrylate alone at control sites. Test sites still > or =5 mm deep at 3 and 6 months were retreated with renewed chlorhexidine chip application. Recordings of bleeding on probing, probing depths, and clinical attachment levels were performed at baseline, after 6 weeks, and after 3, 6, and 9 months.
Improvements of bleeding scores, probing depths and clinical attachment levels were observed for both test and control sites at 6 weeks compared to baseline. Subsequently, all three measurements remained comparatively stable throughout the study. No differences in improvements were found comparing test and control sites.
This study failed to observe any adjunctive effect of subgingival placement of chlorhexidine chips after scaling and root planing.
这项为期9个月的研究旨在比较单纯龈下刮治和根面平整（对照组）与龈下刮治和根面平整加用洗必泰药棒（试验组）的效果。
26名患者参与了这项双盲试验，他们的非磨牙区有两个不相邻的位点，探诊深度≥5mm且探诊出血。基线时，患者接受全口龈下刮治和根面平整，然后在试验组位点用氰基丙烯酸酯固定放置洗必泰药棒，在对照组位点仅放置氰基丙烯酸酯。在3个月和6个月时，试验组中探诊深度仍≥5mm的位点再次放置洗必泰药棒。在基线、6周后以及3、6和9个月后记录探诊出血情况、探诊深度和临床附着水平。
与基线相比试验组位点和对照组位点在6周时探诊出血评分、探诊深度和临床附着水平均有改善。随后，在整个研究过程中，所有这三项测量结果都相对稳定。试验组位点和对照组位点在改善情况上未发现差异。
本研究未观察到龈下刮治和根面平整后放置洗必泰药棒有任何辅助效果。
