Reid W M, Johnson J, Dick J
Avian Dis. 1975 Jan-Mar;19(1):12-8.
The fermentation product lasalocid ("Antibiotic X-537A," Hoffmann-LaRoche) showed good anticoccidial activity when administered via feed at 50 or 75 ppm in a replicated floor-pen experiment. Lasalocid was compared with monensin (121 ppm) ("positive control") and also with unmedicated ("negative") controls in pens heavily seeded or indirectly seeded with eight species of coccidia (Eimeria acervulina, E. brunetti, E. hagani, E. maxima, E. mitati, E. necatrix, E. praecox, and E. tenella). Under severe coccidiosis exposure (litter seeded by infected birds) both anticoccidials permitted significantly increased weights, improved feed conversions, and reduced lesion scores. Shank depigmentation was numerically less in anticoccidial-treated birds than in unmedicated controls, though not significantly. Coccidiosis mortality (lesions or parasites demonstrated) was 10% in unmedicated controls. Lasaloic reduced this mortality significantly to 0.8% at 50 ppm and 0.4% at 75 ppm. No coccidiosis mortality occurred with monensin-fed birds. With moderate exposure (indirect seeding) both anticoccidials permitted significantly greater weight gains and less shank depigmentation than in unmedicated controls. In unmedicated pens severity of coccidiosis was significantly greater in the intentionally seeded pens than in indirectly seeded pens with all parameters except depigmentation. This design provided a practical procedure for testing anticoccidials in a single experiment against severe and moderate exposures to coccidiosis as are normal in broiler production.
发酵产物拉沙洛西（“抗生素X - 537A”，霍夫曼 - 罗氏公司）在一项重复的地面围栏实验中，以50或75 ppm的剂量通过饲料给药时，显示出良好的抗球虫活性。拉沙洛西与莫能菌素（121 ppm）（“阳性对照”）进行了比较，同时也与未用药（“阴性”）对照进行了比较，实验围栏中大量接种或间接接种了八种球虫（堆型艾美耳球虫、布氏艾美耳球虫、哈氏艾美耳球虫、巨型艾美耳球虫、米氏艾美耳球虫、毒害艾美耳球虫、早熟艾美耳球虫和柔嫩艾美耳球虫）。在严重球虫病暴露（感染鸟类接种垫料）的情况下，两种抗球虫药都能显著增加体重、改善饲料转化率并降低病变评分。抗球虫药处理的鸡腿部色素沉着在数值上比未用药对照鸡少，尽管差异不显著。未用药对照的球虫病死亡率（有病变或发现寄生虫）为10%。拉沙洛西在50 ppm时将死亡率显著降低至0.8%，在75 ppm时降至0.4%。饲喂莫能菌素的鸡未出现球虫病死亡。在中度暴露（间接接种）的情况下，两种抗球虫药都比未用药对照鸡体重增加显著更多且腿部色素沉着更少。在未用药围栏中，故意接种的围栏中球虫病的严重程度在除色素沉着外的所有参数上都显著高于间接接种的围栏。这种设计为在单一实验中测试抗球虫药提供了一种实用方法，可针对肉鸡生产中常见的严重和中度球虫病暴露情况。
