Ruff M D, Reid W M, Johnson J K, Anderson W A
Poult Sci. 1979 Mar;58(2):298-303. doi: 10.3382/ps.0580298.
The anticoccidial activity of the ionophorus antibiotic narasin was tested against six species of coccidia (Eimeria acervulina, Eimeria mivati, Eimeria maxima, Eimeria necatrix, Eimeria brunetti, and Eimeria tenella) in battery-raised broilers. Feeding ration medicated with 60, 80, or 100 ppm narasin significantly improved weight gains during the periods of D 0 to D7 and D 0 to D 14 (D 0 = day of inoculation with sporulated oocysts), compared with the weight gains in corresponding inoculated groups fed unmedicated feed. A similar protective effect of the medication was seen with feed conversion ratios (feed consumed/bird weight) and coccidiosis-induced mortality. With most species studied, 40 and 60 ppm narasin was not as efficacious as 80 or 100 ppm. The maximum numerial improvement in weight gain and feed conversion ratio was with 80 ppm narasin. Gross intestinal lesion scores were reduced by medication compared with the scores in birds fed unmedicated feed. The overall trend was for a larger reduction in lesion score with higher drug levels. Narasin at 80 or 100 ppm was generally more effective in controlling individual or mixed species infections of coccidia than 99 ppm monensin.
在笼养肉鸡中，对离子载体抗生素那拉菌素抗球虫活性进行了测试，受试球虫有六种（堆型艾美耳球虫、米氏艾美耳球虫、巨型艾美耳球虫、毒害艾美耳球虫、布氏艾美耳球虫和柔嫩艾美耳球虫）。与相应接种组中饲喂未加药饲料的鸡相比，在日粮中添加60、80或100 ppm那拉菌素显著提高了第0天至第7天以及第0天至第14天期间（第0天 = 接种有孢子化卵囊的日期）的体重增加。在饲料转化率（消耗的饲料/鸡体重）和球虫病诱导的死亡率方面，药物也有类似的保护作用。对于大多数研究的球虫种类，40和60 ppm那拉菌素的效果不如80或100 ppm。体重增加和饲料转化率的最大数值改善出现在添加80 ppm那拉菌素时。与饲喂未加药饲料的鸡相比，药物处理降低了肠道大体病变评分。总体趋势是药物水平越高，病变评分降低幅度越大。80或100 ppm那拉菌素在控制球虫的单一或混合种类感染方面通常比99 ppm莫能菌素更有效。
