Vázquez García V M, Macías Fernández J A, Alonso del Teso F, González las Heras R M, de Teresa Romero G, Alvarez Hurtado A A, Carretero Ares J I
Centro de Salud Tórtola, Facultad de Medicina, Valladolid.
Aten Primaria. 2000 Dec;26(10):697-9. doi: 10.1016/s0212-6567(00)78755-5.
Study of the association between multiple medication and the quality of sleep.
Observational, cross-sectional study through two-stage sampling of 1053 people with a questionnaire and application of the Pittsburgh Sleep Quality Interview (PSQI).
Primary care. Population covered by health centres in the province of Valladolid.
Adults over 18 who attended health centres in Valladolid province.
As consumption of multiple drugs rose, there was significant deterioration in the overall quality of sleep and each of the following components: subjective quality, latency of sleep, duration of sleep, extrinsic disturbances and consumption of sleeping draughts. No differences were found for day-time repercussions. When psychiatric drug consumption was excluded from the study (to avoid the risk of bias in psychiatric illnesses), deterioration in the quality of sleep, on adding up the remaining therapeutic groups of drugs, was still found.
The fact of consuming multiple drugs chronically may condition a deterioration in sleep quality, which will stimulate us to combat this symptom with more drugs and so further aggravate the problem. New prospective studies need to be undertaken to find out the reasons.
研究多种药物与睡眠质量之间的关联。
通过对1053人进行两阶段抽样问卷调查，并应用匹兹堡睡眠质量指数（PSQI）进行的观察性横断面研究。
初级保健。巴利亚多利德省卫生中心覆盖的人群。
在巴利亚多利德省卫生中心就诊的18岁以上成年人。
随着多种药物服用量的增加，睡眠总体质量以及以下各项指标均出现显著恶化：主观睡眠质量、入睡潜伏期、睡眠时间、外在干扰和助眠药物的使用。在日间影响方面未发现差异。当将精神类药物的服用排除在研究之外（以避免精神疾病中的偏倚风险）时，在将其余治疗组药物相加后，仍发现睡眠质量有所恶化。
长期服用多种药物可能会导致睡眠质量下降，这会促使我们使用更多药物来对抗这种症状，从而进一步加剧问题。需要开展新的前瞻性研究以找出原因。
