Karlsson P, Stenberg B, Rosdahl I
Department of Biomedicine and Surgery, Faculty of Health Sciences, University of Linköping, Sweden.
Acta Derm Venereol. 2000 Sep-Oct;80(5):335-9. doi: 10.1080/000155500459259.
The prevalence of common naevi and dysplastic naevi was investigated in a Swedish population with a low incidence of melanoma. A total of 201 subjects aged 30-50 years living in northern Sweden participated. The median number of common naevi per individual was 15, and 11% had dysplastic naevi. Higher numbers of common naevi were found in individuals with dysplastic naevi (median 68) and in those who had spent their childhood in southern Sweden (median 44). The prevalence of common naevi and dysplastic naevi was significantly lower than reported from a previously studied population in southern Sweden, with a melanoma incidence 4 times higher than in the north. The strong variability in naevus phenotype, and in melanoma incidence, between different regions of Sweden seems to be due to different levels of sun exposure rather than to differences in constitutional factors.
在瑞典黑色素瘤发病率较低的人群中,对普通痣和发育异常痣的患病率进行了调查。共有201名年龄在30至50岁之间、居住在瑞典北部的受试者参与。个体普通痣的中位数为15个,11%的人有发育异常痣。发育异常痣患者(中位数为68个)以及在瑞典南部度过童年的人(中位数为44个)的普通痣数量更多。普通痣和发育异常痣的患病率显著低于之前在瑞典南部研究的人群,那里的黑色素瘤发病率比北部高4倍。瑞典不同地区痣的表型以及黑色素瘤发病率的巨大差异似乎是由于不同程度的阳光照射,而非体质因素的差异。