Anderberg U M, Uvnäs-Moberg K
Department of Neuroscience, Psychiatry University Hospital, 75185 Uppsala, Sweden.
Z Rheumatol. 2000 Dec;59(6):373-9. doi: 10.1007/s003930070045.
Fibromyalgia syndrome (FMS) is a chronic pain disorder, where 90% of the patients struck by the disorder are women. The neuropeptide oxytocin is known to have antinociceptive and analgesic, as well as anxiolytic and antidepressant effects, which makes this neuropeptide of interest in fibromyalgia research. The aim of this study was to assess oxytocin concentrations in female FMS patients with different hormonal status and in depressed and non-depressed patients and relate oxytocin concentrations to adverse symptoms as pain, stress, depression, anxiety and to the positive item happiness.
Thirty-nine patients and 30 controls registered these symptoms daily during 28 days and blood samples for the assessment of oxytocin were drawn twice in all patients and controls. Besides the daily ratings, depression was also estimated with the self-rating instrument Beck Depression Inventory (BDI).
Depressed patients according to the BDI differed significantly with low levels of oxytocin compared to the non-depressed patients and the controls. Low levels of oxytocin were also seen in high scoring pain, stress and depression patients according to the daily ratings; however, these subgroups were small. A negative correlation was found between the scored symptoms depression and anxiety and oxytocin concentration, and a positive correlation between the item happiness and oxytocin. The oxytocin concentration did not differ between the hormonally different subgroups of patients or controls.
The results suggest that the neuropeptide oxytocin may, together with other neuropeptides and neurotransmitters, play a role in the integration of the stress axes, monoaminergic systems and the pain processing peptides in the pathophysiologic mechanisms responsible for the symptoms in the FMS.
纤维肌痛综合征（FMS）是一种慢性疼痛疾病，90%的患者为女性。已知神经肽催产素具有抗伤害感受和镇痛作用，以及抗焦虑和抗抑郁作用，这使得该神经肽成为纤维肌痛研究的关注点。本研究的目的是评估不同激素状态的女性纤维肌痛综合征患者以及抑郁和非抑郁患者体内的催产素浓度，并将催产素浓度与疼痛、压力、抑郁、焦虑等不良症状以及积极项目幸福感相关联。
39名患者和30名对照在28天内每天记录这些症状，所有患者和对照均采集两次血样以评估催产素。除了每日评分外，还使用自评工具贝克抑郁量表（BDI）评估抑郁情况。
根据BDI，抑郁患者的催产素水平明显低于非抑郁患者和对照。根据每日评分，在疼痛、压力和抑郁评分高的患者中也发现催产素水平较低；然而，这些亚组规模较小。抑郁和焦虑评分症状与催产素浓度之间呈负相关，幸福感项目与催产素之间呈正相关。患者或对照的不同激素亚组之间的催产素浓度没有差异。
结果表明，神经肽催产素可能与其他神经肽和神经递质一起，在负责纤维肌痛综合征症状的病理生理机制中，在应激轴、单胺能系统和疼痛处理肽的整合中发挥作用。
