Iizuka Y, Sakurai E, Tanaka Y
Department of Pharmaceutics I, Tohoku Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
Yakugaku Zasshi. 2001 Jan;121(1):93-6. doi: 10.1248/yakushi.121.93.
The effects of Selenium (Se) on lipid metabolism was studied in male Wistar rats which were fed a high-cholesterol diet (HCD) containing 1%(w/w) cholesterol and 0.5%(w/w) cholic acid for 10 weeks. Se was orally administered at daily doses of 0.173 mg/kg in HCD into the test rats for 10 weeks. As compared with control groups, Se/HCD suppressed the amounts of triglyceride (TG), total cholesterol (CH) and free fatty acid in the serum. Se/HCD also decreased the amounts of low-density lipoprotein cholesterol (LDL-C) in the serum. Further-more, Se/HCD inhibited the amount of liver TG and CH. The activity of fatty acid synthetase in the HCD fed group was higher than in the Se/HCD fed group. These results suggest that Se may have recuperative effects for hypercholesterolemia.
研究了硒（Se）对雄性Wistar大鼠脂质代谢的影响。这些大鼠被喂食含1%（w/w）胆固醇和0.5%（w/w）胆酸的高胆固醇饮食（HCD），持续10周。将硒以每日0.173mg/kg的剂量口服给予HCD组的实验大鼠，持续10周。与对照组相比，Se/HCD组抑制了血清中甘油三酯（TG）、总胆固醇（CH）和游离脂肪酸的量。Se/HCD组还降低了血清中低密度脂蛋白胆固醇（LDL-C）的量。此外，Se/HCD组抑制了肝脏TG和CH的量。HCD喂养组中脂肪酸合成酶的活性高于Se/HCD喂养组。这些结果表明，硒可能对高胆固醇血症具有恢复作用。
