Goldwyn S, Lazinsky A, Wei H
Department of Dermatology, Mount Sinai Medical Center, New York, NY 10029, USA.
Drug Metabol Drug Interact. 2000;17(1-4):261-89. doi: 10.1515/dmdi.2000.17.1-4.261.
Cardiovascular diseases, osteoporosis-related hip fractures, and various cancers of the colon, prostate, uterus, and breast are remarkably less prevalent in Asia than in other industrialized countries. It is believed that the large consumption of soy products in Asian countries is contributory to the reduction of these chronic disorders. Genistein is a major isoflavone found in most soy products and plays an important role in the promotion of human health. Extensive epidemiological, in vitro, and animal studies have been performed, and most studies indicate that genistein has beneficial effects on a multitude of human disorders, including cancers, cardiovascular diseases, osteoporosis, and postmenopausal symptoms. To date, there is an abundance of promising studies supporting genistein's potential uses, but further research is still needed to validate its preventative and therapeutic efficacy. In addition, the adverse effects of genistein have drawn public attention. More studies are required to assess the potential detrimental effect of genistein, and a benefit-risk ratio should be considered before future clinical studies are performed.
心血管疾病、与骨质疏松症相关的髋部骨折以及结肠、前列腺、子宫和乳腺的各种癌症在亚洲的发病率明显低于其他工业化国家。人们认为，亚洲国家大豆制品的大量消费有助于减少这些慢性疾病。染料木黄酮是大多数大豆制品中含有的一种主要异黄酮，对促进人类健康起着重要作用。已经进行了广泛的流行病学、体外和动物研究，大多数研究表明染料木黄酮对多种人类疾病具有有益作用，包括癌症、心血管疾病、骨质疏松症和绝经后症状。迄今为止，有大量有前景的研究支持染料木黄酮的潜在用途，但仍需要进一步研究来验证其预防和治疗效果。此外，染料木黄酮的不良反应已引起公众关注。需要更多研究来评估染料木黄酮的潜在有害影响，并且在进行未来的临床研究之前应考虑其利弊比。
