Wada Y, Kamiya N, Asano S, Shinya F
Dept. of Surgery, Iwaki Kyoritsu General Hospital.
Gan To Kagaku Ryoho. 2001 Jan;28(1):79-82.
The patient was a 61-year-old woman who had Stage IV advanced gastric cancer with Virchow's and paraaortic lymph node metastases. The lesions were considered surgically incurable, so she was placed on neoadjuvant chemotherapy consisting of low-dose CDDP and 5-FU. After 3 courses of chemotherapy, the tumor had decreased remarkably in size and Virchow's metastasis had disappeared. She was considered to have a partial response (PR) and underwent distal gastrectomy. Histopathological examination of the primary tumor revealed that almost all cancer cells existed in the mucosal and submucosal layers; few had infiltrated the serosa. A few paraaortic lymph nodes were positive for metastasis, but a curative resection (Cur B) was performed. The patient received another course of chemotherapy after the operation. Low-dose CDDP and 5-FU therapy was associated with few adverse events in this case, and thought to be effective against advanced gastric cancer.
该患者为一名61岁女性，患有IV期晚期胃癌，伴有魏尔啸淋巴结和主动脉旁淋巴结转移。这些病变被认为无法通过手术治愈，因此她接受了由低剂量顺铂和5-氟尿嘧啶组成的新辅助化疗。经过3个疗程的化疗后，肿瘤大小显著减小，魏尔啸转移灶消失。她被认为有部分缓解（PR），并接受了远端胃切除术。对原发性肿瘤的组织病理学检查显示，几乎所有癌细胞都存在于黏膜和黏膜下层；很少有癌细胞浸润至浆膜层。少数主动脉旁淋巴结有转移阳性，但仍进行了根治性切除（Cur B）。患者术后接受了另一疗程的化疗。在该病例中，低剂量顺铂和5-氟尿嘧啶治疗的不良事件较少，被认为对晚期胃癌有效。
