Hemminki K, Dong C, Frisch M
Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden.
Eur J Cancer Prev. 2000 Dec;9(6):433-7. doi: 10.1097/00008469-200012000-00010.
The study aimed at probing the possible role of human papillomavirus (HPV) infection in squamous cell carcinomas of the upper aerodigestive tract, with a special reference to tonsillar cancer. We used the Swedish Family Cancer Database to analyse second cancers in the upper aerodigestive tract of women first diagnosed with in-situ or invasive cervical cancer. First cancers of their husbands were also analysed. Standardized incidence ratios (SIRs) were calculated for female and male cancers, adjusted for age at diagnosis, period, sex, socio-economic status and residential area. Among women, increases were observed at many sites, but tonsillar cancers were increased only among women aged 50 years or more at diagnosis of in-situ cervical cancer (SIR 2.58). The increases at these sites are probably ascribed to the effects HPV, smoking, alcohol or their interaction. Husbands of cervical cancer patients developed an excess (SIR over 2.00) of both tonsillar cancer (SIR 2.39 when wife with in-situ cancer and SIR 2.72 when wife with invasive cervical cancer) and cancer of the tongue. The excess of tonsillar cancer among husbands of women with HPV-associated neoplastic lesions of the cervix supports the a priori hypothesis that HPV may be involved in tonsillar carcinogenesis.
该研究旨在探究人乳头瘤病毒（HPV）感染在上呼吸道消化道鳞状细胞癌中可能发挥的作用，尤其关注扁桃体癌。我们利用瑞典家庭癌症数据库，分析首次被诊断为原位或浸润性宫颈癌的女性上呼吸道消化道的二次癌症情况。她们丈夫的首次癌症情况也进行了分析。计算了女性和男性癌症的标准化发病比（SIR），并根据诊断年龄、时期、性别、社会经济地位和居住地区进行了调整。在女性中，许多部位的癌症发病率都有所上升，但仅在原位宫颈癌诊断时年龄在50岁及以上的女性中，扁桃体癌发病率有所增加（SIR为2.58）。这些部位癌症发病率的增加可能归因于HPV、吸烟、饮酒的影响或它们之间的相互作用。宫颈癌患者的丈夫患扁桃体癌（妻子为原位癌时SIR为2.39，妻子为浸润性宫颈癌时SIR为2.72）和舌癌的比例均过高（SIR超过2.00）。宫颈有HPV相关肿瘤病变的女性的丈夫中扁桃体癌比例过高，这支持了HPV可能参与扁桃体致癌过程的先验假设。
