Lehtinen Tuomas, Zhang Luayo, Sundquist Kristina, Sundquist Jan, Waterboer Tim, Lehtinen Matti, Hemminki Kari
FICAN-Mid, Tampere University, Tampere, Finland.
Molecular Genetic Epidemiology Division, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
Cancer Rep (Hoboken). 2025 Sep;8(9):e70333. doi: 10.1002/cnr2.70333.
Human papillomavirus (HPV) infection is associated with tonsillar and base-of-tongue squamous cell carcinomas (TSCC/BOTSCC). We evaluated the relative risk (RR) of TSCC/BOTSCC in the husbands of women with anogenital cancer using the Swedish family database.
The Swedish family database includes 3.5 million families and 16 million individuals identified since 1932 and linked to cancer data from 1958 to 2015. We explored the RR of TSCC/BOTSCC in husbands of women diagnosed with anogenital (anal, vulvar/vaginal, cervical) cancer or cervical carcinoma in situ (CIS) as compared to husbands of controls.
The RR of TSCC/BOTSCC in husbands of women with invasive anogenital cancer increased by calendar time and decreasing ages at diagnoses. In 2002-2015, the RR peaked at 5.35 (95% CI 2.21-13.0) in TSCC/BOTSCC cases diagnosed at age < 50 years. In husbands of women with CIS, the RR for TSCC/BOTSCC was 2-fold irrespective of time period.
Clustering of increased HPV-associated invasive cancer risk in spouses appears to be calendar-time dependent. This introduces a new perspective in cancer science: an increase of familial HPV-associated cancer risk in spouses.
人乳头瘤病毒（HPV）感染与扁桃体和舌根鳞状细胞癌（TSCC/BOTSCC）相关。我们使用瑞典家庭数据库评估了患有肛门生殖器癌的女性的丈夫患TSCC/BOTSCC的相对风险（RR）。
瑞典家庭数据库包括自1932年以来识别出的350万个家庭和1600万人，并与1958年至2015年的癌症数据相关联。我们探究了被诊断患有肛门生殖器（肛门、外阴/阴道、宫颈）癌或原位宫颈癌（CIS）的女性的丈夫与对照组女性的丈夫相比患TSCC/BOTSCC的RR。
患有浸润性肛门生殖器癌的女性的丈夫患TSCC/BOTSCC的RR随时间推移以及诊断时年龄的降低而增加。在2002 - 2015年，年龄<50岁时被诊断为TSCC/BOTSCC的病例中，RR峰值为5.35（95%CI 2.21 - 13.0）。在患有CIS的女性的丈夫中，TSCC/BOTSCC的RR在任何时间段均为2倍。
配偶中HPV相关浸润性癌症风险增加的聚集似乎与时间相关。这为癌症科学引入了一个新观点：配偶中家族性HPV相关癌症风险增加。
