Elstner K, Selai C E, Trimble M R, Robertson M M
Royal Cornwall Hospital, Truro, Cornwall, UK.
Acta Psychiatr Scand. 2001 Jan;103(1):52-9. doi: 10.1034/j.1600-0447.2001.00147.x.
This is the first study to investigate the Quality of Life (QOL) of patients with Gilles de la Tourette's Syndrome (GTS).
One hundred and three out-patients with GTS completed a semi-structured interview and 90 of these completed questionnaires screening for depression, anxiety and obsessive-compulsive behaviour. QOL was measured with the SF-36 and the Quality of Life Assessment Schedule (QOLAS).
Patients with GTS showed significantly worse QOL than a general population sample. They had better QOL than patients with intractable epilepsy as measured by the QOLAS, although the SF-36 showed significant differences on the subscales Role Limitation due to physical problems and Social Functioning only. Factors influencing QOL domains were employment status, tic severity, obsessive-compulsive behaviour, anxiety and depression.
QOL is impaired in patients with GTS. Measurement of QOL could be used alongside conventional measurements to assess benefit of treatment. We recommend the QOLAS and SF-36 be used.
这是第一项调查抽动秽语综合征（GTS）患者生活质量（QOL）的研究。
103名GTS门诊患者完成了一次半结构化访谈，其中90名完成了抑郁、焦虑和强迫行为的问卷调查。使用SF-36和生活质量评估量表（QOLAS）对生活质量进行测量。
GTS患者的生活质量明显低于一般人群样本。通过QOLAS测量，他们的生活质量优于难治性癫痫患者，尽管SF-36仅在因身体问题导致的角色限制和社会功能子量表上显示出显著差异。影响生活质量领域的因素包括就业状况、抽动严重程度、强迫行为、焦虑和抑郁。
GTS患者的生活质量受损。生活质量的测量可与传统测量方法一起用于评估治疗效果。我们建议使用QOLAS和SF-36。
