皮肤癌局部化疗后对5-氟尿嘧啶的迟发型超敏反应。
Delayed hypersensitivity to 5-fluorouracil following topical chemotherapy of cutaneous cancers.
作者信息
Mansell P W, Litwin M S, Ichinose H, Krementz E T
出版信息
Cancer Res. 1975 May;35(5):1288-94.
Skin tests to various common antigens, dinitrochlorobenzene, and 5-fluorouracil (5-FU) were performed on patients being treated for cutaneous neoplasms with topical 5-FU cream. Eleven of 15 patients tested both before and after therapy converted from skin test negative to positive with respect to 5-FU. This conversion correlated with positive dinitrochlorobenzene skin tests and therapeutic cure. The relation between the induction of delayed hypersensitivity reactions to 5-FU following treatment with topical 5-FU and the cure rate for cutaneous neoplasms showed a trend toward correlation.
对正在用外用5-氟尿嘧啶（5-FU）乳膏治疗皮肤肿瘤的患者进行了针对各种常见抗原、二硝基氯苯和5-氟尿嘧啶（5-FU）的皮肤试验。15名患者中有11名在治疗前后均接受了检测，结果显示他们对5-FU的皮肤试验从阴性转为阳性。这种转变与二硝基氯苯皮肤试验阳性及治疗治愈相关。外用5-FU治疗后对5-FU迟发型超敏反应的诱导与皮肤肿瘤治愈率之间的关系呈现出一种相关趋势。
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