急性肝炎患者中地高辛和β-甲基地高辛-12α-3H的药代动力学及代谢

Pharmacokinetics and metabolism of digoxin- and beta-methyl-digoxin-12aplha-3 H in patients with acute hepatitis.

作者信息

Zilly W, Richter E, Rietbrock N

出版信息

Clin Pharmacol Ther. 1975 Mar;17(3):302-9. doi: 10.1002/cpt1975173302.

DOI:10.1002/cpt1975173302

PMID:1120395

Abstract

Pharmocokinetics and metabolism of digoxin and beta-methyldigoxin have been studied in patients with acute hepatits after intravenous administration of both H-labeled glycosides. In contrast to digoxin, the rate of decline of radioactivity after administration of beta-methyldigoxin was significantly retarded in patients with acute hepatitis. The increase in plasma concentration after beta-methyldigoxin to patients with acute hepatitis is probably related to decreased demethylation.

摘要

在静脉注射两种H标记糖苷后，已对急性肝炎患者地高辛和β-甲基地高辛的药代动力学及代谢进行了研究。与地高辛不同，急性肝炎患者注射β-甲基地高辛后放射性下降速率显著减慢。急性肝炎患者注射β-甲基地高辛后血浆浓度升高可能与去甲基化减少有关。