Tomitaka M, Tomitaka S, Otuka Y, Kim K, Matuki H, Sakamoto K, Tanaka A
Department of Psychiatry, Tokyo Women's Medical College, Japan.
Am J Med Genet. 1999 Oct 15;88(5):469-71. doi: 10.1002/(sici)1096-8628(19991015)88:5<469::aid-ajmg6>3.0.co;2-f.
In this study, we investigated the association between dopamine receptor D4 (DRD4) exon III polymorphism and novelty seeking in 69 Japanese women. The group of subjects with long allele (> or =5 repeats) exhibited significantly elevated novelty seeking scores in comparison with subjects lacking the long allele. By contrast, the scores for harm avoidance, reward dependence, and persistence were statistically indistinguishable in the two group of subjects. With regard to the subscales of novelty seeking, the scores for exploratory excitability and extravagance were significantly higher in subjects with the long allele than in subjects lacking the long allele. However, no significant associations with impulsiveness or disorderliness were recognized. Our results suggest that although long alleles of the polymorphic exon III repeats are low in the Japanese population, there is an association between long alleles of DRD4 exon III polymorphism and novelty seeking.
在本研究中，我们调查了69名日本女性中多巴胺受体D4（DRD4）外显子III多态性与寻求新奇之间的关联。与缺乏长等位基因的受试者相比，具有长等位基因（≥5次重复）的受试者组表现出显著升高的寻求新奇得分。相比之下，两组受试者在避免伤害、奖赏依赖和坚持性方面的得分在统计学上无显著差异。关于寻求新奇的分量表，具有长等位基因的受试者在探索兴奋性和放纵性方面的得分显著高于缺乏长等位基因的受试者。然而，未发现与冲动性或无序性有显著关联。我们的结果表明，尽管多态性外显子III重复序列的长等位基因在日本人群中比例较低，但DRD4外显子III多态性的长等位基因与寻求新奇之间存在关联。
