Alonge T O, Wale A
Department of Surgery, University College Hospital, Ibadan, Nigeria.
Afr J Med Med Sci. 1999 Sep-Dec;28(3-4):193-4.
Chronic osteomyelitis is a disease of soft tissue and bone and it is common in the developing countries. The management of this debilitating disease requires the delivery of the appropriate chemotherapeutic agent at the site of the infection after adequate debridement. The search for a suitable carrier for these chemotherapeutic agents is the advent of the 'septopal' or gentamycin-polymethylmethacrylate (gentamycin-PMMA) beads. Septopal beads are expensive and are not affordable by patients in the developing countries. Moreover, most of the micro-organisms (mixed flora) responsible for chronic osteomyelitis in our hospitals are sensitive to ceftriaxone and only in a few cases were gentamycin-sensitive micro-organisms isolated. Therefore, it was imperative that patient-specific and antibiotic-specific PMMA beads would be the way forward and this is the reasoning behind the production of the intra-operative antibiotic bead maker (IABM) and the point of technique is hereby presented.
慢性骨髓炎是一种软组织和骨骼疾病，在发展中国家很常见。治疗这种使人衰弱的疾病需要在充分清创后，将合适的化疗药物输送到感染部位。寻找这些化疗药物的合适载体促成了“Septopal”或庆大霉素-聚甲基丙烯酸甲酯（庆大霉素-PMMA）珠的出现。Septopal珠价格昂贵，发展中国家的患者负担不起。此外，我们医院中导致慢性骨髓炎的大多数微生物（混合菌群）对头孢曲松敏感，只有少数病例分离出对庆大霉素敏感的微生物。因此，定制患者和抗生素特异性的PMMA珠势在必行，这就是术中抗生素珠制造器（IABM）产生的原因，在此介绍其技术要点。
