Cuparencu B, Horák J, Horák A, Tiglea M
Department of Pharmacology, Faculty of Medicine and Pharmacy, University of Oradea, Cluj-Napoca, Romania.
Acta Physiol Hung. 2000;87(2):193-9.
In rats rendered hyperlipidemic by ip administration of Triton WR-1339, the ip administration of zopiclone at doses of 1.25, 2.5, 5.0, 7.5, 10.0 and 15.0 mg/kg, a cyclopyrrolone acting upon the central benzodiazepine receptors, induces very significant reductions of total lipids, total cholesterol, and triglycerides, at nearly all of the doses. The most active dose was 5.0 mg/kg. The blood glucose level was diminished by doses of 1.25, 2.5, 7.5 and 15.0 mg/kg and it was not changed by the rest of the other doses.
通过腹腔注射Triton WR - 1339使大鼠产生高脂血症后，腹腔注射剂量为1.25、2.5、5.0、7.5、10.0和15.0 mg/kg的佐匹克隆（一种作用于中枢苯二氮䓬受体的环吡咯酮），几乎在所有剂量下都能使总脂质、总胆固醇和甘油三酯显著降低。最有效的剂量是5.0 mg/kg。1.25、2.5、7.5和15.0 mg/kg的剂量可降低血糖水平，其余剂量则无此作用。
