Tsukui T, Kashiwagi R, Sakane M, Tabata F, Akamatsu T, Wada K, Futagami S, Miyake K, Sueoka N, Hirakawa T, Kobayashi M, Fujimori T, Sakamoto C
Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
J Gastroenterol Hepatol. 2001 Jan;16(1):15-21. doi: 10.1046/j.1440-1746.2001.02380.x.
The classification of gastritis by using the revised Sydney system suggests that there are two types of Helicobacter pylori-related gastritis. The aim of the present study was to examine the risk factors that might be involved in the presence of either atrophic gastritis or intestinal metaplasia of the gastric corpus of Japanese patients.
Biopsy samples were obtained from the gastric corpus in 154 patients with dyspepsia, and the degree of atrophy or intestinal metaplasia was determined histologically. The correlation between several variables and presence of atrophy or intestinal metaplasia was evaluated by using multivariate analysis.
Among the 11 variables, which included age, peptic ulcer diseases and H. pylori infection, H. pylori infection was the major risk factor associated with the presence of atrophic gastritis or intestinal metaplasia of the gastric corpus. In contrast, duodenal ulcer (DU) disease reduced the risk of contracting both conditions. Age was an independent risk factor only for intestinal metaplasia of the gastric corpus. When 128 H. pylori-positive subjects were analyzed, DU and age were similarly associated with the presence of both conditions.
These results suggest that DU reduces the risk for contracting atrophic gastritis and intestinal metaplasia, and age is an independent risk factor for intestinal metaplasia of the gastric corpus in dyspeptic Japanese patients.
采用修订后的悉尼系统对胃炎进行分类表明，幽门螺杆菌相关胃炎有两种类型。本研究的目的是探讨可能与日本患者胃体萎缩性胃炎或肠化生存在相关的危险因素。
从154例消化不良患者的胃体获取活检样本，通过组织学方法确定萎缩或肠化生的程度。使用多变量分析评估几个变量与萎缩或肠化生存在之间的相关性。
在包括年龄、消化性溃疡疾病和幽门螺杆菌感染在内的11个变量中，幽门螺杆菌感染是与胃体萎缩性胃炎或肠化生存在相关的主要危险因素。相比之下，十二指肠溃疡（DU）疾病降低了患这两种疾病的风险。年龄仅是胃体肠化生的独立危险因素。当对128例幽门螺杆菌阳性受试者进行分析时，DU和年龄与这两种疾病的存在同样相关。
这些结果表明，DU降低了患萎缩性胃炎和肠化生的风险，并且年龄是消化不良的日本患者胃体肠化生的独立危险因素。
