家族史是感染患者胃萎缩进展的独立危险因素。
Family history is an independent risk factor for the progression of gastric atrophy among patients with infection.
作者信息
Nishizawa Toshihiro, Suzuki Hidekazu, Sakitani Kosuke, Yamashita Hiroharu, Yoshida Shuntaro, Hata Keisuke, Kanazawa Takamitsu, Fujiwara Naoto, Kanai Takanori, Yahagi Naohisa, Toyoshima Osamu
机构信息
Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan; Division of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Tokyo, Japan; Division of Gastroenterology and Hepatology, Department Of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Medical Education Center, Keio University School of Medicine, Tokyo, Japan.
出版信息
United European Gastroenterol J. 2017 Feb;5(1):32-36. doi: 10.1177/2050640616642341. Epub 2016 Jun 22.
BACKGROUND AND AIM
Risk factors for progression of gastric atrophy have not been fully elucidated. The aim of this study was to evaluate the risk factors for the development of atrophic gastritis in patients with ( ) infection.
METHODS
We reviewed 206 -infected patients retrospectively. Endoscopic gastric atrophy was classified into closed- and open-type. We conducted univariate and multivariate logistic regression analyses on the contribution of age, sex, body mass index, past history of cancer, the first-degree family history of gastric cancer, habitual smoking and alcohol drinking, and endoscopic findings of gastric ulcer or duodenal ulcer for open-type gastric atrophy.
RESULTS
On multivariate analysis, age (odds ratio = 1.079, 95% confidence interval = 1.048-1.11, < 0.001), family history of gastric cancer (odds ratio = 3.967, 95% confidence interval = 1.414-10.6, = 0.006) and duodenal ulcer (odds ratio = 0.834, 95% confidence interval = 0.711-0.977, = 0.024) were the factors independently associated with open-type gastric atrophy.
CONCLUSIONS
A first-degree family history of gastric cancer, absence of duodenal ulcer, and old age were independent risk factors for the progression of gastric atrophy among -infected patients. Careful examination with upper gastrointestinal endoscopy is necessary in patients with such risk factors.
背景与目的
胃萎缩进展的危险因素尚未完全阐明。本研究旨在评估（ ）感染患者发生萎缩性胃炎的危险因素。
方法
我们回顾性分析了206例感染患者。内镜下胃萎缩分为闭合型和开放型。我们对年龄、性别、体重指数、既往癌症史、胃癌一级家族史、习惯性吸烟和饮酒以及胃溃疡或十二指肠溃疡的内镜检查结果对开放型胃萎缩的影响进行了单因素和多因素逻辑回归分析。
结果
多因素分析显示，年龄（比值比=1.079，95%置信区间=1.048-1.11，<0.001）、胃癌家族史（比值比=3.967，95%置信区间=1.414-10.6，=0.006）和十二指肠溃疡（比值比=0.834，95%置信区间=0.711-0.977，=0.024）是与开放型胃萎缩独立相关的因素。
结论
胃癌一级家族史、无十二指肠溃疡和高龄是感染患者胃萎缩进展的独立危险因素。对于有此类危险因素的患者，有必要进行仔细的上消化道内镜检查。
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