Chen Y, Dales R, Krewski D
Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ontario, Canada.
Respir Med. 2001 Jan;95(1):13-8. doi: 10.1053/rmed.2000.0961.
An association between obesity and asthma has been documented previously, but the nature of this relationship remains unknown. This study aimed to determine if asthma is associated with a sedentary lifestyle which may explain this association. The energy expenditure (EE) on leisure activities was examined in 16,813 subjects, of at least 12 years of age, who participated in the Canadian National Population Health Survey 1994-95. Energy expenditure was calculated by multiplying the duration of leisure-time physical activity by its estimated metabolic energy cost. Asthma was considered to be present if an affirmative response was given to the question, 'Do you have asthma diagnosed by a health professional?' The average EE (+/- standard error) in males was 2.47 (+/- 0.11) kcal kg(-1) day(-1) for asthmatics and 1.98 (+/- 0.03) kcal kg(-1) day(-1) for non-asthmatics. The corresponding average EEs in females were 1.77 (+/- 0.08) and 1.54 (+/- 0.02) kcal kg(-1) day(-1) for asthmatics and non-asthmatics, respectively. The mean EE values decreased with increasing age. A significant interaction between asthma and age was noted with respect to EE; asthmatics tended to have higher mean EE values than non-asthmatics among younger subjects, and lower mean EE values in older subjects. This effect was more pronounced in females than in males. It was concluded that asthmatics were not consistently inactive compared with non-asthmatics. Leisure-time physical activity cannot explain the positive association between obesity and asthma.
肥胖与哮喘之间的关联此前已有记录，但这种关系的本质仍不清楚。本研究旨在确定哮喘是否与久坐不动的生活方式有关，而这种生活方式可能解释了这种关联。对16813名至少12岁的受试者进行了休闲活动能量消耗（EE）的检测，这些受试者参与了1994 - 1995年的加拿大全国人口健康调查。能量消耗通过将休闲时间体力活动的持续时间乘以其估计的代谢能量消耗来计算。如果对“你是否有医生诊断的哮喘？”这个问题给出肯定回答，则认为患有哮喘。哮喘男性受试者的平均EE（±标准误差）为2.47（±0.11）千卡/千克/天，非哮喘男性受试者为1.98（±0.03）千卡/千克/天。哮喘女性受试者和非哮喘女性受试者相应的平均EE分别为1.77（±0.08）和1.54（±0.02）千卡/千克/天。平均EE值随年龄增长而降低。在EE方面，哮喘与年龄之间存在显著的交互作用；在较年轻的受试者中，哮喘患者的平均EE值往往高于非哮喘患者，而在较年长的受试者中则较低。这种效应在女性中比在男性中更明显。研究得出结论，与非哮喘患者相比，哮喘患者并非一直不活动。休闲时间的体力活动无法解释肥胖与哮喘之间的正相关关系。
