Garcia-Aymerich Judith, Varraso Raphaëlle, Antó Josep M, Camargo Carlos A
Center for Research in Environmental Epidemiology (CREAL), Doctor Aiguader 88, 08003 Barcelona, Catalonia, Spain.
Am J Respir Crit Care Med. 2009 Jun 1;179(11):999-1003. doi: 10.1164/rccm.200812-1929OC. Epub 2009 Feb 26.
The potential role of physical activity in preventing asthma exacerbations is unknown.
To investigate the longitudinal association between regular physical activity and asthma exacerbations.
A total of 2,818 women with asthma from a large U.S. cohort (the Nurses' Health Study) were monitored from 1998 to 2000. Physical activity was self-reported at baseline, using a validated questionnaire, and categorized in quintiles. Exacerbations during follow-up were defined as a self-report of asthma-related hospitalization, emergency department visit, or urgent office visit. Baseline information about severity of asthma, treatment, previous exacerbations, sociodemographic factors, smoking, and other potential confounders was obtained.
Participants had a mean age of 63 years, and 71% had mild-to-moderate persistent asthma. About half of the women were ever-smokers (48% former, 6% current), and median physical activity was 10 MET x hours/week (equivalent to walking at a brisk pace for 20 minutes three times per week). Risk of exacerbations during follow-up decreased with increasing level of physical activity. In a multivariate logistic regression model, the higher level of physical activity, the lower risk of admission (odds ratio 0.85, 0.81, 0.78, and 0.76, for the 2nd, 3rd, 4th, and 5th quintiles compared with the 1st quintile, P for trend = 0.05). There were no relevant differences on stratifying by age group, smoking status, body mass index, baseline use of inhaled corticosteroids, or previous exacerbations.
Regular physical activity was associated with reduced risk of exacerbations in women with asthma in this longitudinal study.
体育活动在预防哮喘发作中的潜在作用尚不清楚。
研究规律体育活动与哮喘发作之间的纵向关联。
对来自美国一个大型队列（护士健康研究）的2818名哮喘女性进行了1998年至2000年的监测。在基线时通过一份经过验证的问卷对体育活动进行自我报告，并分为五分位数。随访期间的发作定义为哮喘相关住院、急诊就诊或紧急门诊就诊的自我报告。获取了有关哮喘严重程度、治疗、既往发作、社会人口学因素、吸烟及其他潜在混杂因素的基线信息。
参与者的平均年龄为63岁，71%患有轻度至中度持续性哮喘。约一半女性曾经吸烟（48%为既往吸烟者，6%为当前吸烟者），体育活动的中位数为10梅脱×小时/周（相当于每周三次以轻快步伐步行20分钟）。随访期间发作风险随着体育活动水平的增加而降低。在多因素逻辑回归模型中，体育活动水平越高，入院风险越低（与第一五分位数相比，第二、第三、第四和第五五分位数的比值比分别为0.85、0.81、0.78和0.76，趋势P值 = 0.05）。按年龄组、吸烟状况、体重指数、吸入性糖皮质激素的基线使用情况或既往发作进行分层时，无相关差异。
在这项纵向研究中，规律体育活动与哮喘女性发作风险降低相关。
