Miller D L, Ross E M, Alderslade R, Bellman M H, Rawson N S
Br Med J (Clin Res Ed). 1981 May 16;282(6276):1595-9. doi: 10.1136/bmj.282.6276.1595.
The first 1000 cases notified to the National Childhood Encephalopathy Study were analysed. The diagnoses included encephalitis/encephalopathy, prolonged convulsions, infantile spasms, and Reye's syndrome. Eighty-eight of the children had had a recent infectious disease, including 19 with pertussis. Only 35 of the notified children (3.5%) had received pertussis antigen within seven days before becoming ill. Of 1955 control children matched for age, sex, and area of residence, 34 (1.7%) had been immunised with pertussis vaccine within the seven days before the date on which they became of the same age as the corresponding notified child. The relative risk of a notified child having had pertussis immunisation within that time interval was 2.4 (p less than 0.001). Of the 35 notified children, 32 had no previous neurological abnormality. A year later two had died, nine had developmental retardation, and 21 were normal. A significance association was shown between serious neurological illness and pertussis vaccine, though cases were few and most children recovered completely.
对向国家儿童脑病研究报告的首批1000例病例进行了分析。诊断包括脑炎/脑病、惊厥持续状态、婴儿痉挛症和瑞氏综合征。88名儿童近期患过传染病，其中19名患有百日咳。在报告的儿童中，只有35名（3.5%）在发病前7天内接种过百日咳抗原。在1955名年龄、性别和居住地区相匹配的对照儿童中，34名（1.7%）在达到与相应报告儿童相同年龄的日期前7天内接种了百日咳疫苗。报告儿童在该时间间隔内接种百日咳疫苗的相对风险为2.4（p<0.001）。在35名报告的儿童中，32名以前没有神经异常。一年后，2名儿童死亡，9名发育迟缓，21名正常。尽管病例数较少且大多数儿童完全康复，但严重神经疾病与百日咳疫苗之间显示出显著关联。
