在严格输血指南下对极低和超低出生体重儿进行红细胞输血：外源性促红细胞生成素是否必要？
Red blood cell transfusions in very and extremely low birthweight infants under restrictive transfusion guidelines: is exogenous erythropoietin necessary?
作者信息
Franz A R, Pohlandt F
机构信息
Department of Paediatrics, Division of Neonatology and Paediatric Critical Care, University of Ulm, 89070 Ulm, Germany.
出版信息
Arch Dis Child Fetal Neonatal Ed. 2001 Mar;84(2):F96-F100. doi: 10.1136/fn.84.2.f96.
OBJECTIVE
To examine the number and volume of red blood cell transfusions (RBCTs) in very and extremely low birthweight infants under restrictive red blood cell transfusion guidelines without erythropoietin administration, and to compare the results with those reported in similar infants receiving erythropoietin.
METHODS
From April 1996 to June 1999, all RBCTs given to infants with a birth weight of less than 1500 g were prospectively recorded. Data on RBCT combined with erythropoietin treatment and RBCT guidelines were extracted from four prospective randomised trials of erythropoietin for anaemia of prematurity.
RESULTS
When the restrictive RBCT guidelines were followed, the number of RBCTs and volume transfused were similar to those reported during erythropoietin administration.
CONCLUSIONS
RBCT guidelines may have a similar impact on RBCT in very low birthweight infants to the administration of erythropoietin. The effect of RBCT guidelines on RBCT frequency should be considered when evaluating the efficacy of erythropoietin administration to preterm infants.
目的
在不使用促红细胞生成素的情况下，依据限制性红细胞输血指南，检查极低出生体重和超低出生体重婴儿的红细胞输注（RBCT）数量及输注量，并将结果与接受促红细胞生成素治疗的类似婴儿的报告结果进行比较。
方法
1996年4月至1999年6月，前瞻性记录所有出生体重小于1500g婴儿的RBCT情况。从四项关于促红细胞生成素治疗早产儿贫血的前瞻性随机试验中提取RBCT联合促红细胞生成素治疗及RBCT指南的数据。
结果
遵循限制性RBCT指南时，RBCT数量及输注量与促红细胞生成素治疗期间报告的情况相似。
结论
RBCT指南对极低出生体重婴儿RBCT的影响可能与促红细胞生成素的使用相似。在评估促红细胞生成素对早产儿治疗效果时，应考虑RBCT指南对RBCT频率的影响。
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