Division of Neonatology, Department of Pediatrics, Hangzhou First People's Hospital, Zhejiang, China.
Department of Pediatrics, Hangzhou First People's Hospital, Zhejiang, China.
Sci Rep. 2014 Mar 11;4:4340. doi: 10.1038/srep04340.
Anemia and the need for transfusion of packed red blood cells (PRBCs) are common in preterm infants. PRBC transfusion increases the oxygen carrying capacity of hemoglobin and may result in higher rates of organ dysfunction. To determine whether PRBC transfusion in preterm infants is associated with an increased incidence of bronchopulmonary dysplasia (BPD), this retrospective study was performed on neonates with birth weights ≤ 1,500 g or gestational age ≤ 32 weeks admitted from August, 2008 to November, 2013. Infants who received PRBC transfusion before the diagnosis of BPD and those who did not receive PRBC transfusion or received PRBC transfusion after diagnosis of BPD were compared for incidence of BPD and other morbidities. Of 231 preterm infants, 137 received PRBC transfusion before BPD was diagnosed (group 1) and 94 did not (group 2). The incidence of BPD was significantly higher in group 1 than in group 2 (37.2% vs. 2.1%, P < 0.00001). After adjusting for potential risk factors, the adjusted odds ratio for BPD was 9.80 (95% confidence interval, 1.70-56.36; P = 0.01). This study demonstrated an association between PRBC transfusion and BPD in preterm infants. A cautious approach to PRBC transfusion in these infants is warranted.
贫血和需要输注浓缩红细胞（PRBC）是早产儿常见的问题。PRBC 输血可增加血红蛋白的携氧能力，可能导致更高的器官功能障碍发生率。为了确定早产儿 PRBC 输血是否与支气管肺发育不良（BPD）的发生率增加有关，本回顾性研究对 2008 年 8 月至 2013 年 11 月期间出生体重≤1500g 或胎龄≤32 周的新生儿进行了研究。比较了在 BPD 诊断前接受 PRBC 输血和未接受 PRBC 输血或在 BPD 诊断后接受 PRBC 输血的婴儿的 BPD 发生率和其他并发症。在 231 例早产儿中，137 例在 BPD 诊断前接受了 PRBC 输血（第 1 组），94 例未接受 PRBC 输血或在 BPD 诊断后接受了 PRBC 输血（第 2 组）。第 1 组的 BPD 发生率明显高于第 2 组（37.2%比 2.1%，P<0.00001）。在调整了潜在的危险因素后，BPD 的调整比值比为 9.80（95%置信区间，1.70-56.36；P=0.01）。本研究表明 PRBC 输血与早产儿 BPD 之间存在关联。在这些婴儿中谨慎进行 PRBC 输血是必要的。
