Lanctôt K L, Herrmann N, Mazzotta P
J Neuropsychiatry Clin Neurosci. 2001 Winter;13(1):5-21. doi: 10.1176/jnp.13.1.5.
The behavioral and psychological symptoms of dementia (BPSD) can have serious debilitating effects on the patient and increase caregiver burden. Investigations into the underlying neuropathology indicate that the serotonergic system may contribute to BPSD. In addition, serotonergic pathways are known to interact extensively with the cholinergic, noradrenergic, GABAergic, and dopaminergic systems. Hence, serotonergic therapies may be used to manipulate other neurotransmitters systems to alleviate BPSD or in combination with agents specific for the other neurotransmitter receptor sites. Neurotransmitter-modulated behaviors and evidence provided by pharmacological interventions are reviewed, focusing primarily on the serotonergic system.
痴呆的行为和心理症状（BPSD）会对患者产生严重的衰弱影响，并增加护理人员的负担。对潜在神经病理学的研究表明，血清素能系统可能与BPSD有关。此外，已知血清素能通路与胆碱能、去甲肾上腺素能、GABA能和多巴胺能系统广泛相互作用。因此，血清素能疗法可用于调节其他神经递质系统以减轻BPSD，或与针对其他神经递质受体位点的药物联合使用。本文回顾了神经递质调节的行为以及药理学干预提供的证据，主要关注血清素能系统。
