Chaudhary Shefali, Zhornitsky Simon, Chao Herta H, van Dyck Christopher H, Li Chiang-Shan R
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Department of Medicine, Yale University School of Medicine, New Haven, CT, USA.
Am J Alzheimers Dis Other Demen. 2022 Jan-Dec;37:15333175221082834. doi: 10.1177/15333175221082834.
We described behavioral studies to highlight emotional processing deficits in Alzheimer's disease (AD). The findings suggest prominent deficit in recognizing negative emotions, pronounced effect of positive emotion on enhancing memory, and a critical role of cognitive deficits in manifesting emotional processing dysfunction in AD. We reviewed imaging studies to highlight morphometric and functional markers of hippocampal circuit dysfunction in emotional processing deficits. Despite amygdala reactivity to emotional stimuli, hippocampal dysfunction conduces to deficits in emotional memory. Finally, the reviewed studies implicating major neurotransmitter systems in anxiety and depression in AD supported altered cholinergic and noradrenergic signaling in AD emotional disorders. Overall, the studies showed altered emotions early in the course of illness and suggest the need of multimodal imaging for further investigations. Particularly, longitudinal studies with multiple behavioral paradigms translatable between preclinical and clinical models would provide data to elucidate the time course and underlying neurobiology of emotion processing dysfunction in AD.
我们描述了行为学研究，以突出阿尔茨海默病（AD）中的情绪加工缺陷。研究结果表明，在识别负面情绪方面存在显著缺陷，积极情绪对增强记忆有明显作用，并且认知缺陷在AD情绪加工功能障碍的表现中起关键作用。我们回顾了影像学研究，以突出情绪加工缺陷中海马回路功能障碍的形态学和功能标志物。尽管杏仁核对情绪刺激有反应，但海马功能障碍会导致情绪记忆缺陷。最后，所回顾的涉及AD中焦虑和抑郁的主要神经递质系统的研究支持了AD情绪障碍中胆碱能和去甲肾上腺素能信号的改变。总体而言，这些研究表明在疾病过程早期情绪就发生了改变，并表明需要进行多模态成像以进一步研究。特别是，采用多种可在临床前和临床模型之间转换的行为范式的纵向研究将提供数据，以阐明AD中情绪加工功能障碍的时间进程和潜在神经生物学机制。
