López-Ibor J J
Department of Psychiatry, Hospital Ramon Y Cajal, Madrid, Spain.
Acta Neurochir Suppl (Wien). 1991;52:149-53. doi: 10.1007/978-3-7091-9160-6_40.
When neurobiological investigation looks beyond nosological perspectives into the search for correlations between isolated symptoms or specific behaviour patterns (some of which may be normal) and laboratory findings, many controversies seem to become clear. A paradigm of this approach is the Serotonin (5-HT) involvement in a wide range of psychiatric disorders and specific behaviour patterns all of them characterized by a poor control of impulses. Psychopharmacotherapy with substances able to interfere with the metabolism of this neurotransmitter, mostly antidepressants, are able to compensate what appear to be very dissimilar conditions. Therefore, the hypothesis that Serotonin is important for the control of impulses is a key to the interpretation of many findings and to the penetration of the complex field of biological substrate of psycho (patho) logy.
当神经生物学研究超越疾病分类学视角，转而寻找孤立症状或特定行为模式（其中一些可能是正常的）与实验室检查结果之间的相关性时，许多争议似乎就变得清晰了。这种方法的一个范例是血清素（5-HT）参与多种精神疾病和特定行为模式，所有这些都以冲动控制不佳为特征。使用能够干扰这种神经递质代谢的物质进行心理药物治疗，主要是抗抑郁药，能够补偿看似非常不同的状况。因此，血清素对冲动控制很重要这一假设是解释许多研究结果以及深入理解心理（病理）学复杂生物学基础领域的关键。
